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10.1007/s10529-009-9968-6 43 FengC.LiuH.YangY.HuangB.ZhouY

doi: 10.3389/fpls.2016.00301 Received 13 January 2016 Accepted 25 February 2016 Published 22 March 2016 Volume 7 - 2016 Edited by Richard Sayre, New Mexico Consortium at Los Alamos National Labs, USA Reviewed by Suleyman I

The stability of the dimeric structure is a key factor that determines the pathogenicity of the ALS SOD1 mutants with the interface mutants A4V and I113T causing some of the most aggressive forms of the disease

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182 In addition, d-penicillamine has been shown to inhibit the activity of LOX, thereby resulting in impaired collagen cross-link formation, reduced VEGF expression, and delay the progression of glioblastoma in vivo