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Authorship All the authors have made substantial contribution to the preparation of this manuscript

Smyth MJ, Cretney E, Kelly JM, Westwood JA, Street SE, Yagita H

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

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This means that patients can achieve their weight loss goals without experiencing the unwanted effects often associated with hormone-based therapies