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Description

Approximately 50-70% of adult and pediatric SLE patients have an upregulated IFN signature, a cluster of IFN-stimulated genes, that correlates with disease activity and severity (122)

PMC 3488923

PLoS ONE 7(7):e41945

In the meantime, glutaminase (GLS1) production is driven by the PI3K/AKT/mTORC1 pathway, which sustains mitochondrial oxidative phosphorylation (OXPHOS) via the tricarboxylic acid cycle (TCA) (82)