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Assessing GSH status is critical for studying oxidative stress mechanisms and downstream effects of oxidative damage

A series of combinations of deaminase, reverse transcriptase (RT), or a transcriptional repressor/activator with Cas9 subsequently achieved unprecedented benefits, such as the expression/activation of specific or multiple genes, DNA base pair conversions, or transversions

Nat Commun 16 , 9547 (2025)

Cholesterol can induce PD-1 expression, impede CD8 + T cell proliferation, and diminish levels of toxic cytokines (such as TNF-, IFN-) by amplifying endoplasmic reticulum stress, thereby fostering immune evasion by tumor cells and functional impairment of CD8 + T cells