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Conversely, in some cancers, such as gastric cancer, breast cancer, and melanoma, CHAC1 has been correlated with poor prognosis, suggesting it may also play an oncogenic role

& Paradies, G

Consequently, targeting key regulators of chromosomal instability could offer promising therapeutic avenues for cancers associated with aberrant PcG protein function

doi: 10.1007/s40610-025-00167-2 244 CristoforiFDargenioVNDargenioCMinielloVLBaroneMFrancavillaR

The 2017 Neelakantan paper in Biochemistry characterised a fluorescent assay for direct real-time monitoring of NNMT enzymatic activity, providing the analytical foundation for inhibitor screening including 5-Amino-1MQ (PMID 28121423)