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Analysis of advanced AD brain tissue has shown extensive abnormalities in the IGF signaling pathway compared to elderly controls, with significant downregulation of IGF-1 and its receptor gene expression [5, 6, 131]

Thus, in the setting of IGF-IR resistance in the pituitary and hypothalamus of acromegaly patients, the negative feedback loop by IGF-I may be defective resulting in further IGF-I elevations

Effect of high-dose mineralocorticoid receptor antagonist eplerenone on urinary albumin excretion in patients with type 2 diabetes and high cardiovascular risk: Data from the MIRAD trial