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Cell 33 , ar56 (2022)

NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway

Much of the above was considered purely theoretical, based on observation of human and animal behavior but without direct biologic correlation until 2019 when Professor Connor Liston published a groundbreaking paper in Science , demonstrating the atrophy of dendritic spines on brain cells in the presence of high levels of NMDA activity