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Dysregulated iron homeostasis amplifies ferroptotic susceptibility through Fenton chemistry-driven lipid peroxidation and polyamine synthesis via the ODC1-MYC axis, a metabolic and oxidative cascade prominently observed in the inflamed synovium of rheumatoid arthritis ( Inducing ferroptosis in specific cell populations using agents like Imidazole ketone erastin (IKE) can suppress synovial fibroblast proliferation and inflammation (104)

Watercress and garlic are CYP2E1 inhibitors in humans [59, 60]

This selective receptor interaction enables reproducible activation of intracellular signaling pathways associated with growth hormone synthesis and secretion (10)