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Selected randomly, players are tested at least once a year, but most are asked to give a urine sample multiple times during the season

The types of autoimmune CTDs that are associated with the development of ILD are systemic sclerosis, rheumatoid arthritis, idiopathic inflammatory myositis (polymyositis-dermatomyositis and anti-synthetase syndrome), primary Sjogren syndrome, mixed connective tissue disease, and systemic lupus erythematosus, with various frequency (Table 1) (2)

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The human equivalent dose for the cyano- and methyl-cobalamin drinking water used in these studies is ~5000 g/day (CNCbl10 & MeCbl10) and ~25,000 g/day (CNCbl40 & MeCbl40), which was calculated using the standard human equivalent dose parameters [18]