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Park S, Karuna U, Jeoung NH, et al

While clinical validation of this mechanistic advantage continues to evolve, the dual-inhibition profile positions Polmacoxib as a promising therapeutic option for managing osteoarthritis

Kim et al., 2006

21,22,23 Figure 1 shows a historical timeline summarizing studies on milestones in SIRT family members

Fortunately, various reductases such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), along with reducing compounds-glutathione, vitamin C, and vitamin E, help mitigate the harmful effects of oxidative stress in vivo (Sies, 2021)