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In turn, this promotes apoptosis (cell death) in muscle cells

Peiyu et al., 2023)

Cancer Statistics, 2023

Types of nuclear localization signals and mechanisms of protein import into the nucleus

355 Moreover, TDP-43 aggregates can translocate into mitochondria, triggering mitochondrial DNA release into the cytoplasm and activating inflammatory signaling through the cGAS-STING pathway