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This is why we believe the optimal strategy for taking NAD is by combining daily oral NAD precursors for baseline support with periodic and loading dose IV or injection therapy

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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

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A Chi-square test was used to compare comorbidities, and a Wilcoxon rank sum test or Welchs t-test was used to compare age, as shown in the results section (propensity score matching)