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The average onset is between 18 and 29 years of age, with relatively few cases occurring before puberty or after menopause, suggesting a possible influence of androgenic hormones on skin keratinization

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CS exposure acutely depletes GSH levels We sought to determine the effect of CS exposure on the GSH levels before the adaptive response had been established since many of the GSH changes are established within an acute timeframe

"The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)"