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Down-regulated peroxisome proliferator-activated receptor (PPAR) in lung epithelial cells promotes a PPAR agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD)

Chronic inflammation in the brain triggers immune activation and the release of pro-inflammatory agents, impairing the clearance of neurotoxic substances or directly harming neurons [81]

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Since DFO was first discovered to have an inhibitory effect on ferroptosis caused by erastin and RSL3, DFO is the drug most widely used to inhibit lipid peroxidation-mediated ferroptosis under various conditions ( in vivo and in vitro ( Deferasirox Deferasirox is a membrane-permeable iron chelator and the first oral medication approved by the Food and Drug Administration (FDA) for chronic iron overload in the body caused by multiple blood transfusions

[DOI] [Google Scholar] 47.Bhatt P., Kushwah A