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Supplementary material The Supplementary Material for this article can be found online at: Footnotes 1.^ 2.^ 3.^ 4.^ 5.^ References 1 AebiH

Transsulfuration pathway In addition to being remethylated back to methionine, approximately half of Hcy pool could be metabolized into cysteine through the transsulfuration pathway ( Figure 2 )

Ultra-Ca plus is used in the treatment of rickets, osteomalacia, familial hypophosphatemia, hypoparathyroidism, etc

Its first intracellular step towards NAD + biosynthesis is its phosphorylation by nicotinamide riboside kinases (NRKs), forming NMN, which is then transformed to NAD + by NMNATs [13,40] (Figure 3)

However, unlike those in bacteria and unicellular eukaryotes, PTS in mammals has not yet been clearly investigated [284]