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513 Cardiovascular dysfunction is one important fetal defect brought about by prenatal hypoxia, which may lead to fetal growth restriction and even death

Because copper is also an essential cofactor of superoxide dismutase 1 (SOD1), insufficient copper may lower antioxidant activity and render the brain more vulnerable to oxidative damage (144)

The inhibition of SRXN1 amplifies intracellular ROS levels, leading to oxidative damage, mitochondrial dysfunction and apoptosis in cancer cells