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The following animal experiments were conducted: Rats were randomly assigned into five groups (n = 10, respectively), PH group, 2.7 g/kg ZXGD treatment group, 5.4 g/kg ZXGD treatment group, and 35 mg/kg Sildenafil treatment group rats were firstly intraperitoneally injected with 60 mg/kg MCT to induce PH occurrence for 28 days

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According to the World Health Organization, the global ADE-related mortality rate increased approximately 3.3-fold from 2001 to 2019, with the highest rates occurring in those aged 75 years and older

It was approved by the FDA in 2002 for the treatment of postmenopausal women and men with osteoporosis who are at high risk of fracture

10.1124/dmd.30.8.924 198 VornovJ