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This hypoxia not only promotes oxidative stress but also impairs the availability of essential neurotrophic factors like brain-derived neurotrophic factor (BDNF), which are critical for RGC survival (112)

Nrf2 activation may also drive stem/progenitor cells out of quiescence, leading to premature differentiation and depletion of the stem cell pool 35,36,37,38

The copper ion is essential for the peptides gene-regulatory and antioxidant effects

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In: Banks D et al (ed) Classification, clustering and data mining applications, pp 639648 Agarwal R, Hennings L, Rafferty TM, Letzig LG, McCullough S, James LP, MacMillan-Crow LA, Hinson JA (2012) Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice