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[6] Scientists working with test models also comment that IGF-1 may have a GH independent growth stimulating effect, which with respect to cartilage cells is possibly optimized by the synergistic action with GH

In this synthesis of existing observations, we approach this issue through the examination of reported biomarker responses, which are universally recognized as quantitative metrics of vitamin B-12 status (2935)

2013 reported Phase 2 safety/tolerability of the AOD9604 modified form in obesity

suggesting that, at high concentrations, IGF-1 has effects not simply mediated by suppressing the effect of GH on hepatic insulin sensitivity [129, 209]