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discovered that metformin inhibits the mitochondrial respiratory chain complex to prevent the electron transport from NADH to coenzyme Q, which somewhat lowers mitochondrial basal and maximal respiration and mildly limits ATP synthesis

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doi: 10.2478/prilozi-2021-0024

With the current findings of VEGF and its importance in angiogenesis and endothelial cell proliferation, there is a possibility that VEGF needs to be tapped into to influence wound healing