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Another strategy to alleviate disease-causing effects of autoreactive IgG is to block activating FcRs, thereby preventing pathological IgG-mediated activation of FcR-expressing immune cells

Hydration effects last hours to days

Consequently, CRBN-based proteolysis-targeting chimeras (PROTACs) using the BRD4 ligand JQ1 did not trigger YPEL5-dependent BRD4 BD1 ubiquitylation (Extended Data Fig