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There is a lot of literature known about the use of antibiotics, which has been seen to alter the composition of the guts microbiome and have both short-term and long-term effects (6164)

doi: 10.1016/j.cell.2024.06.026 18 LiaoMYaoDWuLLuoCWangZZhangJet al

We also found that some differential metabolites like trans-cinnamate and sphingosine 1-phosphate was significantly correlated with IL-13, IP-10, IFN-, and Eotaxin ( Padj 0.05), such as 3-hydroxyphenylacetate and prostaglandin H2, were also significantly correlated with IL-12, MCP-1 and IL-7 among patients with MS ( Padj 0.05) ( Figure S6 )

Note: The MEP coloration of the electrostatic potential does not show a strong red color for the phosphate-amino alcohol portion of the molecule as it should to show the strong polar property of that group

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