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In diabetic rats, topical administration of HA-coated BSA NPs resulted in a significantly greater fluorescence intensity (12.28 1.39) compared to uncoated NPs (3.55 0.81), achieving 44% of the fluorescence intensity obtained by IVI

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The authors demonstrated that deficits in PER2 function increase alcohol intake and showed that a mutation in PER2 in humans dampens the severity of alcoholism