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In M1 macrophages, a low ratio of -KG as a result of glutamine producing succinate can enhance their proinflammatory phenotype, which is beneficial for inhibiting the growth of tumor cells and enhancing their own immune function [24, 28] (Fig

doi: 10.1097/RCT.0000000000001707 143 CavalcanteSLCDABarros SilvaPGDHirthCGFredericoIKSFurtadoCLM PessoaCDet al

(Image created using BioRender) Ferroptosis is an ancestral, non-apoptotic, iron-dependent form of cell death driven by oxidative modifications of membrane phospholipids

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