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Experimental evolution studies showed that biofilm growth promotes the development of antimicrobial resistance and tolerance through specific mechanisms that have been recently reviewed 2

In addition, based on the study of betaine in terms of genome methylation, this mechanism may involve the up-regulation of genes involved in de novo synthesis and fatty acid oxidation

Molecules 14 , 682725 (2009)

Although mitochondrial contribution was well studied in physiological and pathological conditions after birth, little is known about mitochondrial involvement during prenatal life in humans