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Structural analysis demonstrates how FOXO4-DRI exploits the unique architecture of senescent cells, where FOXO4 latches onto p53 and prevents it from executing its normal pro-apoptotic function

Microglial activation can result in pro-inflammatory conditions, characterized by the secretion of pathological factors (such as IL-1, TNF-, IL-6, NO, and proteases), or in neuroprotective states, influenced by signals like IL-4, IL-10, IL-13, and transforming growth factor- (TGF-) [50]

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This analysis of AD through network pharmacology provides a promising roadmap for addressing the diseases multifaceted pathology, paving the way for innovative, multi-targeted therapeutic solutions (Figure 2)

Dosage ranges from 4mg to 8mg, and can take as little as 30 minutes to take effect