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This metabolic hyperactivity leads to concurrent mitochondrial DNA (mtDNA) instability and cell-autonomous stress responses, which are mechanistically linked to the development of a hypersecretory phenotype (Sturm et al

Other factors, such as the upregulation of immune checkpoint molecules, including programmed death-ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1), also suppress the immune system (361)

Furthermore, a recent study investigating patients with psoriatic arthritis (PsA) demonstrated that various biologic agents including infliximab, adalimumab, etanercept, golimumab, certolizumab, ustekinumab, and secukinumab were associated with an overall protective effect against liver fibrosis in individuals with MASLD

2014;9(8):e104179

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