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This in turn halts both the methionine cycle and the biopterin cycle

Considering the number of patients and the few reported cases, you can see how rare these reactions really are

Beyond-use window: reconstituted solution has a limited stable life (commonly a few weeks refrigerated)

N Engl J Med 2013;368:149-60

For those who have been dealing with B-12 deficiency-related symptoms like fatigue, brain fog, or irritability, these benefits can be quite noticeable