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Despite the innovative strides in nanotechnology resulting in the development of diverse lymphatic system nanocarriers, most designs remain at the stage of fundamental animal research

In senescent cells, FOXO4 sequesters p53 in the nucleus, preventing it from triggering apoptosis

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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury (Fang et al., 2025)

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