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TQ reduces NF-B transcription factor activity so that MMP-1 expression can be suppressed (103)

In contrast to our results, previous studies revealed that high levels of Pb precipitation was noticed in the gill tissues, owing to direct intact within metal ions in the water during osmoregulation and respiration 88

Considerations: Topical treatments are ideal for mild to moderate pigmentation and can be used alongside other treatments for enhanced effects

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This may partly explain the variable anti-cancer effects observed with metformin, further underscoring the importance of patient selection in PDAC management due to its significant heterogeneity