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11 Cardiac arrhythmia has also been reported and is associated with a cytokine storm-triggered systemic hyperinflammatory state and immune response that may cause injury to cardiac monocytes, resulting in myocardial dysfunction and the ensuing development of arrhythmia

Interestingly, downstream steps in folate metabolism, including dihydropteroate synthase and dihydrofolate reductase, are predicted to carry more flux during chloroquine treatment (Fig

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7nAChRs are involved in immunity, inflammation, and neuroprotection in non-neuronal cells such as astrocytes, microglia, dendritic cells, lymphocytes, macrophages, and endothelial cells (Table