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Cytotoxicity was assessed by measuring lactate dehydrogenase release as previously described [15] and CSE treated cells under conditions tested did not have changes in cell viability that were statistically significantly different from controls and was greater than 85%

To identify potential BNIP3 binding sites in BAX, a protein-peptide interaction study was conducted using a library of 13 synthesised 20-meric BAX peptides immobilised on microarrays (Supplementary Fig