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During the development of atherogenesis, cholesterol facilitates neutrophil recruitment and NET formation, which is mediated by activation of the proinflammatory NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome protein (150)

Alikhani M, Khalighinejad N, Ghalaiani P, Khaleghi MA, Askari E, Gorsky M

Indeed, spontaneous tumors in immunosuppressed individuals indicate that the immune system can provide a significant mechanism for host resistance against cancer and infectious diseases [110,111]