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Glutamate Our earlier study showed that treatment of HT22 cells with glutamate activates PDI-mediated nNOS dimerization, which is followed by accumulation of NO and ROS, and ultimately, ferroptotic cell death [8, 40]

Randomized phase II study of modified FOLFOX-6 in combination with ramucirumab or icrucumab as second-line therapy in patients with metastatic colorectal cancer after disease progression on first-line irinotecan-based therapy

Among them, system Xc (including SLC7A11 and SCL3A2), which are expressed at the cell membrane, are easier to be detected as a cell surface marker of cells undergoing ferroptosis

Mice obtain breeding The wild-type (WT) C57BL/6 mice were obtained from Beijing Viton Lihua Laboratory Animal Technology Co Ltd, and APP/PS1 double transgenic (2 Tg) mice were obtained from Hangzhou Ziyuan Laboratory Animal Technology Co Ltd

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