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Discussion Our findings suggest a direct pathogenic role of increased VEGFA for the manifestation of agerelated lens opacifications and for both neovascular and nonexudative AMDlike pathologies through NLRP3 inflammasomedependent mechanisms

Ribosome display has been used to engineer to a variety of different binding proteins, including single chain variable fragments (scFvs), 583,584 antigen binding fragments (Fabs), 585 designed ankyrin repeat proteins (DARPINs), 586 and single domain antibodies

[1] This unique administration requirement does not constitute a true drug interaction but is essential for therapeutic efficacy

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Editor: Chen-Guang Liu, Shanghai Jiao Tong University, CHINA Received: May 10, 2024