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PROMIS-Fatigue T -scores were also correlated with sulfated metabolites of androgen including androstenediol (3beta,17beta) monosulfate ( r = 0.26, p = 0.0008), 5alpha-androstan-3beta,17beta-diol disulfate ( r = 0.21, p = 0.0083), 5alpha-androstan-3beta,17beta-diol monosulfate ( r = 0.20, p = 0.012), 5alpha-androstan-3alpha,17alpha-diol monosulfate ( r = 0.22, p = 0.0062), and 5alpha-androstan-3beta,17alpha-diol disulfate ( r = 0.17, p = 0.028) (Figure 5)

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These findings indicate that MC4R agonist injection into the amOT suppresses odor-attractive behavior and induces aversive responses to the cue odor

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