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Trimethylamine- N -oxide is an independent risk factor for hospitalization events in patients receiving maintenance hemodialysis

L-carnitine used to treat hyper-ammonia in children with urea-cycle enzyme deficiencies26 and valproate-induced hyper-ammonia.27 The protec tive effects of L-carnitine are centrally mediated by activation of metabotropic Glu receptors at the level of brain ammonia uptake and/or mitochondrial energy metabolism

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