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doi: 10.1111/j.1365-2567.2008.02820.x 130 MenziesFMHenriquezFLAlexanderJRobertsCW

Conclusions and Perspectives The selenoprotein glutathione peroxidase 4 is quickly emerging as an intriguing therapeutic target, owing to its essential role in protecting cellular membranes from oxidative damage

key MAPK pathways, such as ERK1/2, JNK, and p38, control essential cellular processes like proliferation, differentiation, apoptosis, and stress responses

2.2 Mechanical microenvironment 2.2.1 Tumor-associated fibroblasts Fibroblasts are resting in normal tissues, but they can be activated by growth factors secreted by tumor cells and differentiate into myofibroblasts

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