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While emerging evidence, including preclinical studies, early-phase trials, and limited clinical series, suggests that KD may help overcome treatment resistance by suppressing the PI3K/Akt/mTOR pathway, reducing insulin-like growth factor-1 (IGF-1) signaling, and enhancing cancer cell susceptibility to chemotherapy and targeted therapies, robust data from large, randomized controlled trials (RCTs) remain sparse

It encourages cytokine downregulation, decreasing IL-1, IL-6, and TNF levels [42]

3.7 Chondroprotective effects of Se/LDH@PEG-M-modulated macrophage polarization Macrophages M1 polarization in synovial tissues plays a significant role in cartilage degeneration [56]