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Kojic acid, while effective for skin whitening, is limited by its carcinogenic potential and instability during storage (Liu et al., 2024a)

The elevated DNA damage and altered DNA methylation are risks for cancer and play essential roles in neurological, and developmental abnormalities and cognitive defects (66)

Nidah S K, Ashley H B, Jiangnan L, Maria A Q, Lissette G, Maria T A et al

doi: 10.1016/j.tjnut.2024.01.019

(4) the intracavitary, subcutaneous, intramuscular administration, and (5) the ozone insufflation via rectum is the most unreliable administration route because we never know the percentage of the really effective ozone dose insufflated into the rectum