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LE BOUFFANT, L., MARTIN, J.C., DANIEL, H., HENIN, J.P., & NORMAND, C

Collectively, these data suggest ndufs2 -/- zebrafish have enlarged livers with increased yolk lipid accumulation due in part to impaired FAO flux, owing to their upregulated NADH:NAD + ratio that is caused by their genetically-disrupted CI (NADH dehydrogenase) capacity and was likely exacerbated by disrupted one-carbon metabolism in the liver, as in mouse liver NAD(P)H is derived from serine catabolism (4, 34, 64)

doi: 10.1016/j.healun.2023.02.878 Goudarzi, Mohaddeseh H., Robinson, Samuel D., Cardoso, Fernanda C., Lawrence, Nicole, Chin, Yanni, King, Glenn F

doi:10.1164/ajrccm.158.5.9712069 Raff H, Ettema S, Eastwood D, Woodson B