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The three libraries were generated using error-prone PCR as described above, using the following conditions to produce varying levels of mutagenesis: Library 1: 30 M 8-oxo-dGTP, 1 M dPTP, 20 PCR cycles Library 2: 20 M 8-oxo-dGTP, 2 M dPTP, 20 PCR cycles Library 3: 10 M 8-oxo-dGTP, 3 M dPTP, 20 PCR cycles The library sizes (approximated by number of transformants as described above) were 6 10 7 for each library

We have previously identified a compound YMU1, an inhibitor of thymidylate kinase (TMPK), which increased doxorubicin sensitivity of cancer cells by causing DNA repair toxicity 19,20

Although several pieces of data suggest a possible therapeutic effect of GSH, administered directly or through its precursor N-Acetil Cystein (NAC), in drug-induced liver disease (DILI) [112,113], no randomized-controlled clinical trials are available to support this evidence

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium