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Description

The total cellular GSH level was significantly increased at 600 g/ml D-HIS

Participants taking steroid medication were excluded

Its small molecular weight (~390 Da) supports cellular uptake and is reported to enable direct DNA / chromatin interaction at gene promoter regions, consistent with the broader Khavinson bioregulator hypothesis

This study also found that anti-doxorubicin produced inflammation and oxidative stress in the kidneys, and that doxorubicin plus apigenin increased resistance to doxorubicin in breast cancer cells via the JAK/STAT signalling pathway (162)