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Primary MS fatigue is intricately linked to the disease process

Studies have shown that BTZ can sensitize peripheral sensory nerve fibers, resulting in overactivity of WDR neurons and subsequent abnormal pain or nociceptive hypersensitivity (Stockstill et al., 2018

The differences related to insulin sensitivity in cancer patients with or without cachexia might rely on degree of peripheral resistance as additional mechanisms in cancer cachexia, such as adipose tissue alterations and hormonal deregulations (glucagon, GLP-1, ghrelin, vitamin D, testosterone, apelin), in turn enforce it ( In conclusion, a crucial role of both endocrine and exocrine functions of pancreas in cachexia development has been evidenced in patients affected by pancreatic cancer

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The cardiovascular system is uniquely vulnerable to these dramatic metabolic shifts, which is particularly relevant for patients dealing with dysautonomia and postural orthostatic tachycardia syndrome (POTS)