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Moreover, anti-MMP-9 antibody treatment in C3HeB/FeJ mice led to the development of hypoxic TB granulomas and cavitary lesions, resulting in a lower relapse rate, although this was not significantly different [138]

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In many cases, what is interpreted as angiogenic activity may instead reflect other forms of vascular remodelingsuch as BBB disruption, pericyte loss, or basement membrane alterationsrather than true neovascularization

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