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Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor PJ, Neki A, Abe T, Nakanishi S, Mizuno N

Moreover, an important consequence of ethanol and acetaldehyde oxidation is an increase in both cytosolic and mitochondrial NADH/NAD ratios, which elevate the activity of xanthine oxidase, a free-radical generating enzyme