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Detection of ascorbyl radicals in the blood and extracellular fluid of animal models has been used as evidence for a pro-oxidant role for vitamin C, i.e., they are an intermediate in the reduction of transition metal ions (Chen et al., 2007, 2008)

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Although many of them (such as human) have been sequenced, only few of them have been characterised

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The utility of other nutraceuticals with anti-inflammatory activity such as lipoic acid, creatine, curcumin, or beetroot in the prevention and treatment of HF-associated muscle wasting needs further studies [162, 163]