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Supporting our results, pharmacological interventions with other NAD + precursors including nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and stimulation of autophagy with rapamycin show anti-senescence properties and autophagic reactivation [69, 70]

doi: 10.1016/j.ebiom.2018.01.021 221 VanItallieTB

doi: 10.1038/s41586-024-07135-3 31 DolinaJSVan Braeckel-BudimirNThomasGDSalek-ArdakaniS

For more significant changes in skin tone or the fading of persistent dark spots, consistent use for 3 to 6 months is typically required

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