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Inhibiting the PI3K/AKT/mTOR circuit compromises the viability and function of MDSCs [74]

Other studies have shown that curcumin attenuated cisplatin-induced nephrotoxicity and enhanced its anticancer activity in SD rats, demonstrating its potential role in breast cancer chemotherapy, and cumulative treatment augmented peroxisome proliferator-activated receptor- (PPAR-) expression while lessening BDNF expression in mammary tumors [130]