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Compared with WT, gsnor1 mutant plants exhibited strongly reduced NR activity, while GSNOR1 -overexpressing plants ( 35S::FLAG-GSNOR1 , Supplementary Fig

The findings highlight pathways such as fibroblast-to-myofibroblast transition (FMT), redox balance regulation, lysosomal dysfunction, ETC dysfunction, autophagy, and calcium dysregulation as potential contributors to hEDS pathogenesis